Lycorine
Cat. No.：YN251462
| 产品名称: | Lycorine |
| CAS No.: | 476-28-8 |
| Chemical Name: | (1S,2S,12bS,12cS)-2,4,5,7,12b,12c-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol |
| Synonyms: | 番石榴碱 |
| 分子量: | 287.31 |
| 分子式: | C₁₆H₁₇NO₄ |
| SMILES: | O[C@@H]1[C@@H](O)C=C(CC2)[C@@]3([H])N2CC4=C([C@@]31[H])C=C(OCO5)C5=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Lycorine 是从金眼科植物科中提取的天然生物碱。Lycorine 是强效具有口服活性的SCAP抑制剂，Kd值 15.24 nM。Lycorine 下调 SCAP 蛋白水平而不改变其转录。Lycorine 也是黑色素瘤血管生成抑制剂。Lycorine 有潜力用于前列腺癌和代谢疾病的研究。 |
| IC50和靶点: | |
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Sener, B., Orhan, I., and Satayavivad, J.Antimalarial activity screening of some alkaloids and the plant extracts from AmaryllidaceaePhytother. Res.17(10),1220-1223(2003)
Li, S.-Y., Chen, C., Zhang, H.-Q., et al.Identification of natural compounds with antiviral activities against SARS-associated coronavirusAntiviral Res.67(1),18-23(2005)
Lamoral-Theys, D., Andolfi, A., Van Goietsenoven, G., et al.Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: An investigation of structure-activity relationship and mechanistic insightJ. Med. Chem.52(20),6244-6256(2009)
Liu, J., Yang, Y., Xu, Y., et al.Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replicationVirol. J.8,483(2011)
