alpha-Mangostin
Cat. No.：YN251469
CAS No. ：6147-11-1
| 产品名称: | alpha-Mangostin |
| CAS No.: | 6147-11-1 |
| Chemical Name: | 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one |
| Synonyms: | α-Mangostin |
| 分子量: | 410.46 |
| 分子式: | C₂₄H₂₆O₆ |
| SMILES: | O=C1C2=C(OC3=C1C(C/C=C(C)\C)=C(OC)C(O)=C3)C=C(O)C(C/C=C(C)\C)=C2O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | alpha-Mangostin (α-Mangostin) 是具有广泛生物活性的膳食呫吨酮，如抗氧化剂，抗过敏，抗病毒，抗菌，抗炎和抗癌作用。它是IDH1突变体 (IDH1-R132H) 的抑制剂，Ki值为 2.85 μM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Iinuma, M., Tosa, H., Tanaka, T., et al.Antibacterial activity of xanthones from guttiferaeous plants against methicillin-resistant Staphylococcus aureusJ. Pharm. Pharmacol.48(8),861-865(1996)
Jiang, H.Z., Quan, X.F., Tian, W.X., et al.Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostanaBioorg. Med. Chem. Lett.20(20),6045-6047(2010)
Chen, S.-X., Wan, M., and Loh, B.-N.Active constituents against HIV-1 protease from Garcinia mangostanaPlanta Med.62(4),381-382(1996)
Chen, L.-G., Yang, L.-L., and Wang, C.-C.Anti-inflammatory activity of mangostins from Garcinia mangostanaFood Chem. Toxicol.46(2),688-693(2008)
Johnson, J.J., Petiwala, S.M., Syed, D.N., et al.α-Mangostin, a santhone from mangosteen fruit, promotes cell cycle arrest in prostate cancer and decreases xenograft tumor growthCarcinogenesis33(2),413-419(2012)
Zhang, Y., Sun, Z., Pei, J., et al.Identification of α-mangostin as an agonist of human STINGChemMedChem13(19),2057-2064(2018)
