Coptisine chloride
Cat. No.：YN251526
| 产品名称: | Coptisine chloride |
| CAS No.: | 6020-18-4 |
| Chemical Name: | 6,7-dihydro-bis[1,3]benzodioxolo[5,6-a:4′,5′-g]quinolizinium, monochloride |
| Synonyms: | 盐酸黄连碱 |
| 分子量: | 355.77 |
| 分子式: | C₁₉H₁₄ClNO₄ |
| SMILES: | C1(C(CC[N+]2=C1C=C(C=C3)C(C4=C3OCO4)=C2)=C5)=CC6=C5OCO6.[Cl-] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Coptisine chloride 是从黄连中分离到的生物碱，是一种有效的非竞争性的IDO抑制剂，Ki值为 5.8 μM，IC50值为 6.3 μM。Coptisine chloride 是一种有效的 H1N1 神经氨酸酶 (NA-1) 抑制剂，IC50为 104.6 μg/mL，可用于甲型流感病毒 (H1N1) 感染。 |
| IC50和靶点: | [{name:"IDO:6.3 μM (IC50)"},{name: "IDO:5.8 μM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Jung, H.A., Min, B.S., Yokozawa, T., et al.Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloidsBiol. Pharm. Bull.32(8),1433-1438(2009)
Yu, D., Tao, B.-B., Yang, Y.-Y., et al.The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's diseaseJ. Alzheimers Dis.43(1),291-302(2015)
Li, L., Sun, S., Weng, Y., et al.Interaction of six protoberberine alkaloids with human organic cation transporters 1, 2 and 3Xenobiotica46(2),175-183(2016)
Rao, P.C., Begum, S., Sahai, M., et al.Coptisine-induced cell cycle arrest at G2/M phase and ractive oxygen species-dependent mitochondria-mediated apoptosis in non-small-cell lung cancer A549 cellsTumour Biol.39(3),1-13(2017)
He, K., Ye, X., Wu, H., et al.The safety and anti-hypercholesterolemic effect of coptisine in syrian golden hamstersLipids50(2),185-194(2015)
