Chaetocin
Cat. No.：YN251574
| 产品名称: | Chaetocin |
| CAS No.: | 28097-03-2 |
| Chemical Name: | 2,2',3S,3'S,5aR,5'aR,6,6'-octahydro-3,3'-bis(hydroxymethyl)-2,2'-dimethyl-[10bR,10'bR(11aS,11'aS)-bi-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4,4'-tetrone |
| Synonyms: | 毛壳素 |
| 分子量: | 696.84 |
| 分子式: | C₃₀H₂₈N₆O₆S₄ |
| SMILES: | O=C([C@@](N1C)(SS2)CO)N3[C@](NC4=CC=CC=C54)([H])[C@]5([C@@]6(C7=CC=CC=C7N8)[C@@]8([H])N(C9=O)[C@](C%10=O)(SS[C@]9(CO)N%10C)C6)C[C@]32C1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Chaetocin是组蛋白甲基转移酶(HMT) SU(VAR)3-9的特异性抑制剂，IC50值为0.6 μM。Chaetocin也可抑制硫氧还蛋白还原酶(TrxR)，IC50值为4 μM。 |
| IC50和靶点: | |
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Greiner, D., Bonaldi, T., Eskeland, R., et al.Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9Nat. Chem. Biol.1(3),143-145(2005)
Isham, C.R., Tibodeau, J.D., Jin, W., et al.Chaetocin: A promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stressBlood109(6),2579-2588(2007)
Tibodeau, J.D., Benson, L.M., Isham, C.R., et al.The anticancer agent chaetocin is a competitive substrate and inhibitor of thioredoxin reductaseAntioxid. Redox Signal.11(5),1097-1106(2009)
Bissinger, E.M., Heinke, R., Sippl, W., et al.Targeting epigenetic modifiers: Inhibitors of histone methyltransferasesMed. Chem. Commun.1(2),(2010)
Spannhoff, A., Sippl, W., and Jung, M.Cancer treatment of the future: Inhibitors of histone methyltransferasesInt. J. Biochem. Cell Biol.41,4-11(2009)
Copeland, R.A., Solomon, M.E., and Richon, V.M.Protein methyltransferases as a target class for drug discoveryNat. Rev. Drug Discov.8,724-732(2009)
