Anacardic Acid
Cat. No.：YN251575
| 产品名称: | Anacardic Acid |
| CAS No.: | 16611-84-0 |
| Chemical Name: | 2-hydroxy-6-pentadecyl-benzoic acid |
| Synonyms: | 漆树酸; Hydroginkgolic acid |
| 分子量: | 348.52 |
| 分子式: | C₂₂H₃₆O₃ |
| SMILES: | O=C(O)C1=C(CCCCCCCCCCCCCCC)C=CC=C1O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Anacardic Acid 是从从腰果壳中提取液中分离到的酸类物质，为histone acetyltransferases抑制剂，对 p300 和 PCAF 的IC50值分别为 ∼8.5 μM 和 ∼5 μM。 |
| IC50和靶点: | [{name:"p300-HAT:8.5 μM (IC50)"},{name: "PCAF:5 μM (IC50)"}] |
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Satoh, M., Takeuchi, N., Fujita, T., et al.Synthesis of anacardic acids utilizing an annelation reaction of isoxazoles with ethyl acetoacetateChem. Pharm. Bull. (Tokyo)46(10),1501-1505(1998)
Balasubramanyam, K., Swaminathan, V., Ranganathan, A., et al.Small molecule modulators of histone acetyltransferase p300J. Biol. Chem.278(21),19134-19140(2003)
Sung, B., Pandey, M.K., Ahn, K.S., et al.Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-κB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-κBα kinase, leading to potentiation of apoptosisBlood111,4880-4891(2008)
