Fumitremorgin C
Cat. No.：YN251582
| 产品名称: | Fumitremorgin C |
| CAS No.: | 118974-02-0 |
| Chemical Name: | 1,2,3,5aS,6,11,12S,14aS-octahydro-9-methoxy-12-(2-methyl-1-propen-1-yl)-5H,14H-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione |
| Synonyms: | 12α |
| 分子量: | 379.45 |
| 分子式: | C₂₂H₂₅N₃O₃ |
| SMILES: | O=C([C@]1([H])CC2=C([C@H](/C=C(C)\C)N13)NC4=C2C=CC(OC)=C4)N5[C@](CCC5)([H])C3=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Fumitremorgin C是有效，选择性的ABCG2/BRCP抑制剂。 |
| IC50和靶点: | |
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Rabindran, S.K., He, H., Singh, M., et al.Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin CCancer Res.58(24),5850-5858(1998)
Rabindran, S.K., Ross, D.D., Doyle, L.A., et al.Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance proteinCancer Res.60(1),47-50(2000)
van Loevezijn, A., Allen, J.D., Schinkel, A.H., et al.Inhibition of BCRP-mediated drug efflux by fumitremorgin-type indolyl diketopiperazinesBioorg. Med. Chem. Lett.11(1),29-32(2001)
