Psammaplin A
Cat. No.：YN251583
CAS No. ：110659-91-1
| 产品名称: | Psammaplin A |
| CAS No.: | 110659-91-1 |
| Chemical Name: | (αE,α'E)-N,N'-(Dithiodi-2,1-ethanediyl)bis[3-bromo-4-hydroxy-α-(hydroxyimino)benzenepropanamide]; (E,E)-Psammaplin A; Bisprasin; Psammaplin A; UVI 5000; (E,E)-N,N'-(Dithiodi-2,1-ethanediyl)bis[3-bromo-4-hydroxy-α-(hydroxyimino)-benzenepropanamide] |
| Synonyms: | |
| 分子量: | 664.39 |
| 分子式: | C₂₂H₂₄Br₂N₄O₆S₂ |
| SMILES: | O=C(NCCSSCCNC(/C(CC1=CC(Br)=C(O)C=C1)=N/O)=O)/C(CC2=CC(Br)=C(O)C=C2)=N/O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Psammaplin A 是一种海洋代谢产物，是HDAC和 DNA 甲基转移酶 (DNA methyltransferases) 的有效抑制剂。Psammaplin A 是一种高效的选择性HDAC1抑制剂，IC50为 0.9 nM，对HDAC1的选择性是 DAC6 的 360 倍，对 HDAC7 和 HDAC8 的效力低 1000 倍以上。Psammaplin A 对革兰氏阳性细菌 (Gram-positive bacteria) 具有抗菌作用，并抑制DNA合成和 DNA 促旋酶 (DNA gyrase) |
| IC50和靶点: | |
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