Rhapontigenin
Cat. No.：YN251589
| 产品名称: | Rhapontigenin |
| CAS No.: | 500-65-2 |
| Chemical Name: | 5-[(1E)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]-1,3-benzenediol |
| Synonyms: | 丹叶大黄素,Protigenin |
| 分子量: | 258.27 |
| 分子式: | C₁₅H₁₄O₄ |
| SMILES: | OC1=CC(/C=C/C2=CC=C(OC)C(O)=C2)=CC(O)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Rhapontigenin 是白藜芦醇的天然类似物，具有抗癌，抗氧化剂，抗真菌和抗菌活性。 Rhapontigenin 是强效选择性细胞色素P450 1A1抑制剂 (IC50=400 nM)。Rhapontigenin 对 P450 1A1 的选择性分别是 P450 1A2 和 P450 1B1 的 400 和 23 倍。 |
| IC50和靶点: | [{name:"CYP1A1:400 nM (IC50)"}] |
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Chun, Y.J., Ryu, S.Y., Jeong, T.C., et al.Mechanism-based inhibition of human cytochrome P450 1A1 by rhapontigeninDrug Metab. Dispos.29(4),389-393(2001)
Roupe, K.A., Helms, G.L., Halls, S.C., et al.Preparative enzymatic synthesis and HPLC analysis of rhapontigenin: Applications to metabolism, pharmacokinetics and anti-cancer studiesJ. Pharm. Pharm. Sci.8(3),374-386(2005)
Roberti, M., Pizzirani, D., Simoni, D., et al.Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agentsJ. Med. Chem.46(16),3546-3554(2003)
