Piperlongumine
Cat. No.：YN251592
CAS No. ：20069-09-4
| 产品名称: | Piperlongumine |
| CAS No.: | 20069-09-4 |
| Chemical Name: | 5,6-dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-2(1H)-pyridinone |
| Synonyms: | 荜茇酰胺; Piplartine |
| 分子量: | 317.34 |
| 分子式: | C₁₇H₁₉NO₅ |
| SMILES: | O=C1C=CCCN1C(/C=C/C2=CC(OC)=C(OC)C(OC)=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Piperlongumine 是从荜茇中得到的生物碱，具有抗炎、抗菌、抗血管生成、抗氧化、抗肿瘤和抗糖尿病等活性。在肿瘤细胞中，Piperlongumine 能够诱导 ROS 和凋亡。Piperlongumine 具有抗心肌纤维化的作用，通过抑制 ERK1/2 信号通路抑制肌成纤维细胞的转化。 |
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Zheng, J., Son, D.J., Gu, S.M., et al.Piperlongumine inhibits lung tumor growth via inhibition of nuclear factor kappa B signaling pathwaySci. Rep.6,26357(2016)
Xu, P., Xiao, J., and Chi, S.Piperlongumine attenuates oxidative stress, inflammatory, and apoptosis through modulating the GLUT-2/4 and AKT signaling pathway in streptozotocin-induced diabetic ratsJ. Biochem. Mol. Toxicol.35(6),1-12(2021)
Harshbarger, W., Gondi, S., Ficarro, S.B., et al.Structural and biochemical analyses reveal the mechanism of glutathione S-transferase pi 1 inhibition by the anti-cancer compound piperlongumineJ. Biol. Chem.292(1),112-120(2017)
