Aflatoxin B1
Cat. No.：YN251674
| 产品名称: | Aflatoxin B1 |
| CAS No.: | 1162-65-8 |
| Chemical Name: | 2,3,6aR,9aS-tetrahydro-4-methoxy-1H,11H-cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione |
| Synonyms: | 黄曲霉毒素B1 |
| 分子量: | 312.27 |
| 分子式: | C₁₇H₁₂O₆ |
| SMILES: | COC1=CC(O[C@]2([H])[C@@]3([H])C=CO2)=C3C(O4)=C1C(CCC5=O)=C5C4=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Aflatoxin B1 (AFB1) 是一类 1A 级致癌物质，是Aspergillus flavus和A. parasiticus的次生代谢产物。Aflatoxin B1 (AFB1) 主要通过诱导抑癌基因 p53 中 codon 249 第三位点的 G-->T，从而引起突变。 |
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Essigmann, J.M., Croy, R.G., Nadzan, A.M., et al.Structural identification of the major DNA adduct formed by aflatoxin B1 in vitroProc. Natl. Acad. Sci. USA74(5),1870-1874(1977)
Aguilar, F., Hussain, S.P., and Cerutti, P.Aflatoxin B1 induces the transversion of G -> T in codon 249 of the p53 tumor suppressor gene in human hepatocytesProc. Natl. Acad. Sci. USA90(18),8586-8590(1993)
Wogan, G.N., Paglialunga, S., and Newberne, P.M.Carcinogenic effects of low dietary levels of aflatoxin B1 in ratsFd. Cosmet. Toxicol.12(5-6),681-685(1974)
