Cytochalasin D
Cat. No.：YN251683
| 产品名称: | Cytochalasin D |
| CAS No.: | 22144-77-0 |
| Chemical Name: | (3S,3aR,4S,6S,6aR,7E,10S,12R,13E,15R,15aR)-15-(acetyloxy)-3,3a,4,5,6,6a,9,10,12,15-decahydro-6,12-dihydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-1H-cycloundec[d]isoindole-1,11(2H)-dione |
| Synonyms: | 细胞松弛素D; Zygosporin A; NSC 209835 |
| 分子量: | 507.62 |
| 分子式: | C₃₀H₃₇NO₆ |
| SMILES: | C=C1[C@@H](O)[C@@]2([H])[C@@]3([C@H](OC(C)=O)/C=C/[C@](O)(C)C([C@@H](C)C/C=C/2)=O)[C@@]([C@H](CC4=CC=CC=C4)NC3=O)([H])[C@@H]1C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cytochalasin D (Zygosporin A; NSC 209835) 是一种有效、细胞渗透性的肌动蛋白聚合抑制剂，由真菌产生，通过绑定 G-actin 抑制 G-actin–cofilin 的相互作用。Cytochalasin D 还能抑制 cofilin 与 F-actin 的结合，降低了活细胞中肌动蛋白聚合和解聚的速率。Cytochalasin D 可以减少外泌体的释放，进而减少肿瘤环境中 survivin 的量。 Cytochalasin D 诱导 YAP 磷酸化，阻止其核易位保留在胞 |
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Brenner, S.L., and Korn, E.D.The effects of cytochalasins on actin polymerization and actin ATPase provide insights into the mechanism of polymerizationJ. Biol. Chem.255(3),841-844(1980)
Lin, D.C., Tobin, K.D., Grumet, M., et al.Cytochalasins inhibit nuclei-induced actin polymerization by blocking filament elongationJ. Cell Biol.84(2),455-460(1980)
Ostlund, R.E., Jr., Leung, J.T., and Hajek, S.V.Regulation of microtubule assembly in cultured fibroblastsJ. Cell Biol.85(2),386-391(1980)
Pinder, J.C., and Gratzer, W.B.Structural and dynamic states of actin in the erythrocyteJ. Cell Biol.96(3),768-775(1983)
Flaumenhaft, R., Dilks, J.R., Rozenvayn, N., et al.The actin cytoskeleton differentially regulates platelet α-granule and dense-granule secretionBlood105(10),3879-3887(2005)
Taheri-Talesh, N., Horio, T., Araujo-Bazán, L., et al.The tip growth apparatus of Aspergillus nidulansMol. Biol. Cell19(4),1439-1449(2008)
dos Santos, T., Varela, J., Lynch, I., et al.Effects of transport inhibitors on the cellular uptake of carboxylated polystyrene nanoparticles in different cell linesPLoS One6(9),1-10(2011)
Nightingale, T.D., White, I.J., Doyle, E.L., et al.Actomyosin II contractility expels von Willebrand factor from Weibel-Palade bodies during exocytosisJ. Cell Biol.194(4),613-629(2011)
Hayot, C., Debeir, O., Van Ham, P., et al.Characterization of the activities of actin-affecting drugs on tumor cell migrationToxicol. Appl. Pharmacol.211,30-40(2006)
