4-Bromo A23187
Cat. No.：YN251689
| 产品名称: | 4-Bromo A23187 |
| CAS No.: | 76455-48-6 |
| Chemical Name: | 6-bromo-5-(methylamino)-2-[[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid |
| Synonyms: | 4-Bromo A23187 |
| 分子量: | 602.52 |
| 分子式: | C₂₉H₃₆BrN₃O₆ |
| SMILES: | CC1C2(OC(C(C)CC2)CC3=NC4=C(C=C(Br)C(NC)=C4C(O)=O)O3)OC(C(C)C(C5=CC=CN5)=O)C(C)C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 4-Bromo A23187 是 A-23187 的卤代类似物。A-2318 是一种高选择性钙离子载体。4-Bromo A23187 是一种钙 (calcium) 调节剂，可诱导细胞凋亡 (apoptosis)，比如 HL-60 细胞。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Deber, C.M., Tom-Kun, J., Mack, E., et al.Bromo-A23187: A nonfluorescent calcium ionophore for use with fluorescent probesAnal. Biochem.146(2),349-352(1985)
Ducreux, S., Gregory, P., and Schwaller, B.Inverse regulation of the cytosolic Ca2+ buffer parvalbumin and mitochondrial volume in muscle cells via SIRT1/PGC-1α axisPLoS One7(9),(2012)
Yang, J., Singh, V., Cha, B., et al.NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cellsJ. Biol. Chem.288(23),16960-16974(2013)
