Thiolutin
Cat. No.：YN251696
| 产品名称: | Thiolutin |
| CAS No.: | 87-11-6 |
| Chemical Name: | N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)-acetamide |
| Synonyms: | Acetopyrrothin |
| 分子量: | 228.29 |
| 分子式: | C₈H₈N₂O₂S₂ |
| SMILES: | CC(NC1=C2C(N(C)C1=O)=CSS2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Thiolutin (Acetopyrrothin) 是由链霉菌 (Streptomyces) 产生的含二硫化物的抗生素和抗血管的化合物。Thiolutin 抑制 JAB1/MPN/Mov34 (JAMM) 金属蛋白酶 Csn5, SHAM-Domain-of-STAM (AMSH) 相关的分子以及特异性去泛素酶 Brcc36。Thiolutin 是有效和选择性内皮细胞粘附的抑制剂，可以快速诱导热休克蛋白β-1 (Hsp27) 磷酸化。 |
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Jimenez, A., Tipper, D.J., and Davies, J.Mode of action of thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiaeAntimicrob. Agents Chemother.3(6),729-738(1973)
Tipper, D.J.Inhibition of yeast ribonucleic acid polymerases by thiolutinJ. Bacteriol.116(1),245-256(1973)
Khachatourians, G.G., and Tipper, D.J.Inhibition of messenger ribonucleic acid synthesis in Escherichia coli by thiolutinJ. Bacteriol.119(3),795-804(1974)
Dai, S., Jia, Y., Wu, S.L., et al.Comprehensive characterization of heat shock protein 27 phosphorylation in human endothelial cells stimulated by the microbial dithiole thiolutinJ. Proteome Res.7(10),4384-4395(2008)
Jia, Y., Wu, S.L., Isenberg, J.S., et al.Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeletonCell Stress Chaperones15,165-181(2010)
