Swainsonine
Cat. No.：YN251700
| 产品名称: | Swainsonine |
| CAS No.: | 72741-87-8 |
| Chemical Name: | (1S,2R,8aR)-octahydro-indolizinetriol |
| Synonyms: | Tridolgosir |
| 分子量: | 173.21 |
| 分子式: | C₈H₁₅NO₃ |
| SMILES: | O[C@@H]1[C@H](O)CN2CCC[C@@H](O)[C@]12[H] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Swainsonine 是从紫云英属植物中分离得到的生物碱类，为 α-甘露糖苷酶 (α-mannosidase) 抑制剂，具有抗肿瘤活性。 |
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Tulsiana, D.R.P., Broquist, H.P., and Touster, O.Marked differences in the swainsonine inhibition of rat liver lysosomal α-D-Mannosidase, Rat Liver Golgi Mannosidase II, and Jack Bean α-D-MannosidaseArch. Biochem. Biophys.236,427-434(1985)
Dennis, J.W., Koch, K., Yousefi, S., et al.Growth inhibition of human melanoma tumor xenografts in athymic nude mice by swainsonineCancer Res.50,1867-1872(1990)
Reddy, B.V.V.G., and Kalraiya, R.D.Sialilated β1,6 branched N-oligosaccharides modulate adhesion, chemotaxis, and motility of melanoma cells: Effect on invasion and spontaneous metastasis propertiesBiochim. Biophys. Acta1760,1393-1402(2006)
Sun, J.Y., Zhu, M.Z., Wang, S.W., et al.Inhibition of the growth of human gastric carcinoma in vivo and in vitro by swainsoninePhytomedicine14,353-359(2007)
