Gliotoxin
Cat. No.：YN251702
| 产品名称: | Gliotoxin |
| CAS No.: | 67-99-2 |
| Chemical Name: | 2,3R,5aS,6S-tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10aR-epidithiopyrazino[1,2-a]indole-1,4-dione |
| Synonyms: | Aspergillin |
| 分子量: | 326.39 |
| 分子式: | C₁₃H₁₄N₂O₄S₂ |
| SMILES: | O=C1N(C)[C@@]2(CO)C(N3[C@@]1(SS2)CC4=CC=C[C@H](O)[C@@]34[H])=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Gliotoxin 是一种次生代谢产物，是A. fumigatus分泌的最丰富的霉菌毒素，抑制巨噬细胞的吞噬作用和其他免疫细胞的免疫功能。Gliotoxin 通过阻止 IκB 降解来抑制诱导型NF-κB活性，从而诱导宿主细胞凋亡 (apoptosis)。_x000D_ Gliotoxin 可以激活PKA并增加细胞内 cAMP 浓度; 调节肌动蛋白细胞骨架重排以促进A. fumigatus内化到肺上皮细胞。 |
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Kwon-Chung, K.J., and Sugui, J.A.What do we know about the role of gliotoxin in the pathobiology of Aspergillus fumigatus?Med. Mycol.47(Suppl 1),S97-S103(2009)
Kroll, M., Arenzana-Seisdedos, F., Bachelerie, F., et al.The secondary fungal metabolite gliotoxin targets proteolytic activities of the proteasomeChem. Biol.6(10),689-698(1999)
Pahl, H.L., Krauss, B., Schulze-Osthoff, K., et al.The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-κBJ. Exp. Med.183(4),1829-1840(1996)
Anselmi, K., Stolz, D.B., Nalesnik, M., et al.Gliotoxin causes apoptosis and necrosis of rat Kupffer cells in vitro and in vivo in the absence of oxidative stress: Exacerbation by caspase and serine protease inhibitionJ. Hepatol.47(1),103-113(2007)
Orciuolo, E., Stanzani, M., Canestraro, M., et al.Effects of Aspergillus fumigatus gliotoxin and methylprednisolone on human neutrophils: Implications for the pathogenesis of invasive aspergillosisJ. Leukoc. Biol.82(4),839-848(2007)
Aljofan, M., Sganga, M.L., Lo, M.K., et al.Antiviral activity of gliotoxin, gentian violet and brilliant green against Nipah and Hendra virus in vitroVirol. J.6,187(2009)
König, Pace, S., Pein, H., et al.Gliotoxin from Aspergillus fumigatus abrogates leukotriene B4 formation through inhibition of leukotriene A4 hydrolaseCell. Chem. Biol.26(4),524-534(2019)
Vigushin, D.M., Mirsaidi, N., Brooke, G., et al.Gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with antitumor activity against breast cancer in vivoMed. Oncol.21(1),21-30(2004)
