Bafilomycin B1
Cat. No.：YN251706
| 产品名称: | Bafilomycin B1 |
| CAS No.: | 88899-56-3 |
| Chemical Name: | 4-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-4-oxo-2E-butenoic acid, (2R,4R,5S,6R)-tetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2 |
| Synonyms: | 巴佛洛霉素 B1 |
| 分子量: | 815.99 |
| 分子式: | C₄₄H₆₅NO₁₃ |
| SMILES: | O=C(O[C@@H]1C[C@@]([C@@H](C)[C@H](O)[C@@H]([C@H]([C@@H](OC)/C=C/C=C(C)/C[C@H](C)[C@H](O)[C@H](C)/C=C(C)/C=C2\OC)OC2=O)C)(O)O[C@H](C(C)C)[C@H]1C)/C=C/C(NC3=C(O)CCC3=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bafilomycin B1 是从链霉菌属中分离得到的大环内酯类抗生素，可抑制革兰氏阳性菌和真菌，同时为大肠杆菌 K+依赖性 ATPase 的抑制剂。 |
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Bowman, E.J., Siebers, A., and Altendorf, K.Bafilomycins: A class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cellsProc. Natl. Acad. Sci. USA85(21),7972-7976(1988)
Yamamoto, A., Tagawa, Y., Yoshimori, T., et al.Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cellsCell Struct. Funct.23(1),33-42(1998)
Shacka, J.J., Klocke, B.J., and Roth, K.A.Autophagy, bafilomycin and cell death: The "A-B-Cs" of plecomacrolide-induced neuroprotectionAutophagy2(3),228-230(2006)
Papini, E., de Bernard, M., Bugnoli, M., et al.Cell vacuolization induced by Helicobacter pylori: Inhibition by bafilomycins A1, B1, C1 and DFEMS Microbiol. Lett.113(2),155-159(1993)
Carr, G., Williams, D.E., Díaz-Marrero, A.R., et al.Bafilomycins produced in culture by Streptomyces spp. isolated from marine habitats are potent inhibitors of autophagyJ. Nat. Prod.73(3),422-427(2010)
Xie, X., Lu, S., Pan, X., et al.Antiviral bafilomycins from a feces-inhabiting Streptomyces sp.J. Nat. Prod.84(2),537-543(2021)
