Radicicol
Cat. No.：YN251709
| 产品名称: | Radicicol |
| CAS No.: | 12772-57-5 |
| Chemical Name: | (4E)-8-chloro-1aR,14R,15,15aR-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2Z]benzoxacyclotetradecin-6,12(7H)-dione |
| Synonyms: | 根赤壳菌素; Monorden |
| 分子量: | 364.78 |
| 分子式: | C₁₈H₁₇ClO₆ |
| SMILES: | OC1=C2C(CC(/C=C/C=C\[C@@H](O3)[C@H]3C[C@@H](C)OC2=O)=O)=C(Cl)C(O)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Radicicol 是Hsp90的抑制剂，IC50值为 1 μM。Radicicol 靶向 Hsp90，与 Hsp90 的 ATP 酶结构域结合并阻止 Hsp90 蛋白成熟，导致蛋白酶体降解。Radicicol 是一种具有抗疟疾活性的抗真菌抗生素 (antifungal antibiotic)，通过靶向恶性疟原虫拓扑异构酶 VIB 来削弱线粒体复制。 |
| IC50和靶点: | [{name:"HSP90:1 μM (IC50)'}, 'Plasmodium'] |
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Kato, M., Li, J., Chuang, J.L., et al.Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicolStructure15(8),992-1004(2007)
Sharma, S.V., Agatsuma, T., and Nakano, H.Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicolOncogene16,2639-2645(1998)
Schulte, T.W., Akinaga, S., Soga, S., et al.Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biological activities with geldanamycinCell Stress Chaperones3(2),100-108(1998)
Hur, E., Kim, H.H., Choi, S.M., et al.Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1 α/aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat-shock protein inhibitor radicicolMol. Pharmacol.62(5),975-982(2002)
Gadelle, D., Bocs, C., Graille, M., et al.Inhibition of archaeal growth and DNA topoisomerase VI activities by the Hsp90 inhibitor radicicolNucleic Acids Res.33(7),2310-2317(2005)
