Nonactin
Cat. No.：YN251715
| 产品名称: | Nonactin |
| CAS No.: | 6833-84-7 |
| Chemical Name: | (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-2,5,11,14,20,23,29,32-octamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone |
| Synonyms: | 无活菌素; Ammonium ionophore I |
| 分子量: | 736.93 |
| 分子式: | C₄₀H₆₄O₁₂ |
| SMILES: | O=C(O[C@H](C)C[C@@]1([H])CC[C@@](O1)([H])[C@H](C)C(O[C@@H](C)C[C@]2([H])CC[C@](O2)([H])[C@@H](C)C(O[C@H](C)C[C@@]3([H])CC[C@@](O3)([H])[C@@H]4C)=O)=O)[C@H](C)[C@@](O5)([H])CC[C@@]5([H])C[C@H](C)OC4=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Nonactin 来源于Streptomyces griseus， 是一种抗生素，作为K+和NH4+载体。Nonactin 是一种氧化磷酸化 (OXPHOS) 解偶联剂。Nonactin 选择性诱导含突变 β-catenin 的细胞凋亡。Nonactin 抑制内源性HSP60表面表达。 |
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Pampaloni, F., Mayer, B., Kabat Vel-Job, K., et al.A novel cellular spheroid-based autophagy screen applying live fluorescence microscopy identifies nonactin as a strong inducer of autophagosomal turnoverSLAS Discov.22(5),558-570(2017)
Hall, J.E., and Latorre, R.Nonactin-K+ complex as a probe for membrane asymmetryBiophys.J.16(1),99-103(1976)
Browne, A., and O'Donnell, M.J.Ammonium secretion by Malpighian tubules of Drosophila melanogaster: Application of a novel ammonium-selective microelectrodeJ. Exp. Biol.216(Pt 20),3818-3827(2013)
Skulskii, I.A., Saris, N.-E.L., Savina, M.V., et al.Uptake of thallous ions by mitochondria is stimulated by nonactin but not by respiration aloneEur. J. Biochem.120(2),263-266(1981)
Beck, J., Gerlach, H., Prelog, V., et al.Metabolic products of actinomycetes. XXXV. Constitution of the macrotetrolides, monactin, dinactin, and trinactinHelv. Chim. Acta45,620-630(1962)
Harold, F.M., and Baarda, J.R.Effects of nigericin and monactin on cation permeability of Streptococcus faecalis and metabolic capacities of potassium-depleted cellsJ. Bacteriol.95(3),816-823(1968)
Laprade, R., Grenier, F., Pagé-Dansereau, M., et al.Carrier-mediated ion transport in lipid bilayer membranesCan. J. Biochem. Cell Biol.62(8),738-751(1984)
Shikata, Y., Kiga, M., Futamura, Y., et al.Mitochondrial uncoupler exerts a synthetic lethal effect against β-catenin mutant tumor cellsCancer Sci.108(4),772-784(2017)
Zhang, Y., Tian, D., Matsuyama, H., et al.Human adenine nucleotide translocase (ANT) modulators identified by high-throughput screening of transgenic yeastJ. Biomol. Screen.21(4),381-390(2016)
Graven, S.N., Lardy, H.A., and Estrada-O, S.Antibiotics as tools for metabolic studies. 8. Effect of nonactin homologs on alkali metal cation transport and rate of respiration in mitochondriaBiochem.6(2),365-371(1967)
Tamai, Y., Toume, K., Arai, M.A., et al.Nonactin and related compounds found in a screening program for Wnt signal inhibitory activityHeterocycles84(2),1245-1250(2012)
Umland, S.P., Shah, H., Jakway, J.P., et al.Effects of cyclosporin A and dinactin on T-cell proliferation, interleukin-5 production, and murine pulmonary inflammationAm. J. Respir. Cell Mol. Biol.20(3),481-492(1999)
