Meleagrin
Cat. No.：YN251716
| 产品名称: | Meleagrin |
| CAS No.: | 71751-77-4 |
| Chemical Name: | (3E,7aR,12aS)-7a-(1,1-dimethyl-2-propen-1-yl)-7a,12-dihydro-6-hydroxy-3-(1H-imidazol-5-ylmethylene)-12-methoxy-1H,5H-imidazo[1',2':1,2]pyrido[2,3-b]indole-2,5(3H)-dione |
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| 分子量: | 433.46 |
| 分子式: | C₂₃H₂₃N₅O₄ |
| SMILES: | O=C1N[C@@]23N(OC)C4=C(C=CC=C4)[C@]2(C(C)(C)C=C)C=C(O)C(N3/C1=C/C5=CN=CN5)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Meleagri 是由青霉属 (Penicillium) 真菌产生的具有抗微生物和抗增殖活性的罗奎福汀 C 衍生生物碱。Meleagrin 是一类FabI抑制剂。Meleagri 是一种主要的c-Met抑制实体，有助于控制 c-Met 依赖性转移和侵袭性乳腺癌。 |
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Zheng, C.J., Sohn, M.J., Lee, S., et al.Meleagrin, a new FabI inhibitor from Penicillium chryosogenum with at least one additional mode of actionPLoS One8(11),(2013)
Ali, H., Ries, M.I., Nijland, J.G., et al.A branched biosynthetic pathway is involved in production of roquefortine and related compounds in Penicillium chrysogenumPLoS One8(6),(2013)
Ries, M.I., Ali, H., Lankhorst, P.P., et al.Novel key metabolites reveal further branching of the roquefortine/meleagrin biosynthetic pathwayJ. Biol. Chem.288(52),37289-37295(2013)
