Netropsin dihydrochloride
Cat. No.：YN251718
| 产品名称: | Netropsin dihydrochloride |
| CAS No.: | 18133-22-7 |
| Chemical Name: | 4-[[2-[(aminoiminomethyl)amino]acetyl]amino]-N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-1-methyl-1H-pyrrole-2-carboxamide, dihydrochloride |
| Synonyms: | |
| 分子量: | 503.39 |
| 分子式: | C₁₈H₂₈Cl₂N₁₀O₃ |
| SMILES: | O=C(C1=CC(NC(CNC(N)=N)=O)=CN1C)NC2=CN(C)C(C(NCCC(N)=N)=O)=C2.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Netropsin (dihydrochloride) 是一种小分子(MGB) 小沟结合剂，抑制分离的拓扑异构酶的催化活性，并干扰拓扑异构酶 II 和 I 在细胞核中的可降解复合物的稳定性。Netropsin (dihydrochloride) 通过以非插入方式与 dsDNA 结合而具有潜在的抗生素和抗病毒特性，它通过干扰 HMGA1 DNA 与核心NOS2 启动子的结合来减弱 NOS2 的诱导作用，从而提高小鼠内毒素血症的存活率。DNA 溶液中 的 Netropsin (dihydrochloride) |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Neidle, S.DNA minor-groove recognition by small moleculesNat. Prod. Rep.18(3),291-309(2001)
Finlay, A.C., Hochstein, F.A., Sobin, B.A., et al.Netropsin, a new antibiotic produced by a StreptomycesJ. Am. Chem. Soc.73(1),341-343(1951)
Wartell, R.M., Larson, J.E., and Wells, R.D.Netropsin. A specific probe for A-T regions of duplex deoxyribonucleic acidJ. Biol. Chem.249(21),6719-6731(1974)
Beerman, T.A., Woynarowski, J.M., Sigmund, R.D., et al.Netropsin and bis-netropsin analogs as inhibitors of the catalytic activity of mammalian DNA topoisomerase II and topoisomerase cleavable complexesBiochim. Biophys. Acta1090(1),52-60(1991)
Becker, Y., Asher, Y., and Zakay-Rones, Z.Congocidine and distamycin A, antipoxvirus antibioticsAntimicrob. Agents Chemother.1(6),483-488(1972)
Grant, M.A., Baron, R.M., Macias, A.A., et al.Netropsin improves survival from endotoxaemia by disrupting HMGA1 binding to the NOS2 promoterBiochem. J.418(1),103-112(2009)
