Siomycin A
Cat. No.：YN251837
CAS No. ：12656-09-6
| 产品名称: | Siomycin A |
| CAS No.: | 12656-09-6 |
| Chemical Name: | N-[(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-valyl-2,3-didehydroalanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12, |
| Synonyms: | 盐霉素 A |
| 分子量: | 1648.84 |
| 分子式: | C₇₁H₈₁N₁₉O₁₈S₅ |
| SMILES: | O=C1N[C@]23[C@@](N=C(C4=NC(C(NC(C(NC(C(N)=O)=C)=O)=C)=O)=CS4)CC3)([H])C5=CSC([C@@]([C@H](OC(C6=CC([C@@H](O)C)=C7C([C@](O)([H])[C@@H](C=C7)N[C@](C(C)C)([H])C(NC(C(NC(C(N[C@H]1C)=O)=C)=O)=C)=O)=N6)=O)C)([H])NC(C8=CSC([C@](NC([C@]9([H])N=C(SC9)/C(NC(C([C@H]( |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Siomycin A 是一种硫肽抗生素，也是一种Forkhead box M1(FOXM1)选择性抑制剂，而且不影响 Forkhead box 家族其他成员。Siomycin A 具有抗肿瘤作用并促进细胞凋亡。 |
| IC50和靶点: | |
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Tori, K., Tokura, K., Yoshimura, Y., et al.1H NMR spectral evidence for the structure and conformation of peptide antibiotic siomycin-AJ. Antibiot. (Tokyo)32(10),1072-1077(1979)
Radhakrishnan, S.K., Bhat, U.G., Hughes, D.E., et al.Identification of a chemical inhibitor of the oncogenic transcription factor forkhead box M1Cancer Res.66(19),9731-9735(2006)
Gartel, A.L.Thiazole antibiotics siomycin A and thiostrepton inhibit the transcriptional activity of FOXM1Front. Oncol.3,150(2013)
Nakano, I., Joshi, K., Visnyei, K., et al.Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathwayNeuro. Oncol.13(6),622-634(2011)
Joshi, K., Banasavadi-Siddegowda, Y., Mo, X., et al.MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cellsStem Cells31(6),1051-1063(2013)
Bhat, U.G., Halasi, M., and Gartel, A.L.Thiazole antibiotics target FoxM1 and induce apoptosis in human cancer cellsPLoS One4(5),e5592(2009)
