Taurolidine
Cat. No.：YN251915
CAS No. ：19388-87-5
| 产品名称: | Taurolidine |
| CAS No.: | 19388-87-5 |
| Chemical Name: | 4,4'-methylenebis(tetrahydro-1,2H,4-thiadiazine) 1,1,1',1'-tetraoxide |
| Synonyms: | 牛磺罗定 |
| 分子量: | 284.35 |
| 分子式: | C₇H₁₆N₄O₄S₂ |
| SMILES: | O=S1(NCN(CN(CC2)CNS2(=O)=O)CC1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Taurolidine 是一种广谱的抗菌剂 (antimicrobial)，用于预防中心静脉导管相关感染。Taurolidine 能通过诱导细胞凋亡 (apoptosis) 对脑肿瘤细胞有直接和选择性的抗肿瘤作用。 |
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Calabresi, P., Goulette, F.A., and Darnowski, J.W.Taurolidine: Cytotoxic and mechanistic evaluation of a novel antineoplastic agentCancer Res.61(18),6816-6821(2001)
Caruso, F., Darnowski, J.W., Opazo, C., et al.Taurolidine antiadhesive properties on interaction with E. coli; its transformation in biological environment and interaction with bacteria cell wallPLoS One5(1),e8927(2010)
Watson, R.W., Redmond, H.P., McCarthy, J., et al.Taurolidine, an antilipopolysaccharide agent, has immunoregulatory properties that are mediated by the amino acid taurineJ. Leukoc. Biol.58(3),299-306(1995)
Chromik, A.M., Daigeler, A., Bulut, D., et al.Comparative analysis of cell death induction by taurolidine in different malignant human cancer cell linesJ. Exp. Clin. Cancer Res.29(1),21(2010)
Stendel, R., Biefer, H.R., Dékány, G.M., et al.The antibacterial substance taurolidine exhibits anti-neoplastic action based on a mixed type of programmed cell deathAutophagy5(2),194-210(2009)
Aceto, N., Bertino, P., Barbone, D., et al.Taurolidine and oxidative stress: A rationale for local treatment of mesotheliomaEur. Respir .J.34(6),1399-1407(2009)
