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3-Nitropropanoic acid

Cat. No.:YN251920

  • CAS No. :504-88-1

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    • 参考文献
    • 产品名称: 3-Nitropropanoic acid
      CAS No.: 504-88-1
      Chemical Name: 3-nitro-propanoic acid
      Synonyms:3-硝基丙酸; β-Nitropropionic acid; Bovinocidin
      分子量:119.08
      分子式:C₃H₅NO₄
      SMILES:O=C(O)CC[N+]([O-])=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: 3-Nitropropanoic acid (β-Nitropropionic acid) 是琥珀酸脱氢酶的不可逆抑制剂。3-Nitropropanoic acid 具有很强的抗分枝杆菌活性,MIC 值为 3.3μM。
      IC50和靶点:
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    • Brouillet, E., Hantraye, P., Ferrante, R.J., et al.Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primatesProc. Natl. Acad. Sci. USA92,7105-7109(1995)

      Huang, L., Sun, G., Cobessi, D., et al.3-Nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzymeJ. Biol. Chem.281(9),5965-5972(2006)

      Ayala-Peña, S.Role of oxidative DNA damage in mitochondrial dysfunction and Huntington's disease pathogenesisFree Radic. Biol. Med.62,102-110(2013)

      Zuchora, B., Tursji, W.A., Wielosz, M., et al.Protective effect of adenosine receptor agonists in a new model of epilepsy--seizures evoked by mitochondrial toxin, 3-nitropropionic acid, in miceNeurosci. Lett.305(2),91-94(2001)

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