Chromomycin A3
Cat. No.：YN251951
| 产品名称: | Chromomycin A3 |
| CAS No.: | 7059-24-7 |
| Chemical Name: | (1S)-1-C-[(2S,3S)-7-[[4-O-acetyl-2,6-dideoxy-3-O-(2,6-dideoxy-4-O-methyl-α-D-lyxo-hexopyranosyl)-β-D-lyxo-hexopyranosyl]oxy]-3-[[O-4-O-acetyl-2,6-dideoxy-3-C-methyl-α-L-arabino-hexopyranosyl-(1→3)-O-2,6-dideoxy-β-D-arabino-hexopyranosyl-(1→3)-2,6-dideoxy- |
| Synonyms: | |
| 分子量: | 1183.25 |
| 分子式: | C₅₇H₈₂O₂₆ |
| SMILES: | O=C1C2=C(C[C@H]([C@@H]1O[C@](C[C@@H](O[C@](C[C@@H](O[C@@]3([H])C[C@](O)([C@H]([C@@H](O3)C)OC(C)=O)C)[C@@H]4O)([H])O[C@@H]4C)[C@@H]5O)([H])O[C@@H]5C)[C@@H](C([C@H]([C@@H](C)O)O)=O)OC)C=C(C=C6O[C@H]7C[C@H]([C@H]([C@H](O7)C)OC(C)=O)O[C@]8([H])C[C@H]([C@H]([C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Chromomycin A3 是一种金黄色素型抗肿瘤抗生素。Chromomycin A3 与二价阳离子形成二聚体复合物，例如 Mg2+，其强烈结合富含 GC 的 DNA 序列以抑制 DNA 复制和转录。Chromomycin A3 具有多种用途，可作为人精子染色质，自噬诱导剂和凋亡抑制剂的染色剂。 |
| IC50和靶点: | |
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Crissman, H.A., and Tobey, R.A.Methods in cell biology33,(1990)
Van Dyke, M.W., and Dercan, P.B.Chromomycin, mithramycin, and olivomycin binding sites on heterogeneous deoxyribonucleic acid. Footprinting with (methidiumpropyl-EDTA)iron(II).Biochemistry22(10),2373-2377(1983)
Schwarzacher, T.Methods in molecular biology1370,(2016)
Miller, S.C., Huang, R., Sakamuru, S., et al.Identification of known drugs that act as inhibitors of NF-κB signaling and their mechanism of actionBiochem. Pharmacol.79(9),1272-1280(2016)
Chatterjee, S., Zaman, K., Ryu, H., et al.Sequence-selective DNA binding drugs mithramycin A and chromomycin A3 are potent inhibitors of neuronal apoptosis induced by oxidative stress and DNA damage in cortical neurons.Ann. Neurol.49(3),345-354(2001)
