Bosutinib
Cat. No.：YN440038
CAS No. ：380843-75-4
规格
价格(RMB)
库存
| 产品名称: | Bosutinib |
| CAS No.: | 380843-75-4 |
| Chemical Name: | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile |
| Synonyms: | SKI-606 |
| 分子量: | 530.45 |
| 分子式: | C₂₆H₂₉Cl₂N₅O₃ |
| SMILES: | CN1CCN(CC1)CCCOC2=C(C=C3C(NC4=CC(OC)=C(C=C4Cl)Cl)=C(C=NC3=C2)C#N)OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bosutinib是Src/Abl的双抑制剂，IC50分别为1.2 nM和1 nM。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Boschelli, D.H., Ye, F., Wang, Y.D., et al.Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activityJ. Med. Chem.44,3965-3977(2001)
Golas, J.M., Arndt, K., Etienne, C., et al.SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude miceCancer Res.63(2),375-381(2003)
Remsing Rix, L.L., Rix, U., Colinge, J., et al.Global target profile of the kinase inhbitor bosutinib in primary chronic myeloid leukemia cellsLeukemia23,477-485(2009)
