Nilotinib
Cat. No.：YN440039
CAS No. ：641571-10-0
规格
价格(RMB)
库存
| 产品名称: | Nilotinib |
| CAS No.: | 641571-10-0 |
| Chemical Name: | 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-benzamide |
| Synonyms: | 尼洛替尼; AMN107 |
| 分子量: | 529.52 |
| 分子式: | C₂₈H₂₂F₃N₇O |
| SMILES: | O=C(NC1=CC(C(F)(F)F)=CC(N2C=NC(C)=C2)=C1)C3=CC=C(C)C(NC4=NC=CC(C5=CC=CN=C5)=N4)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Nilotinib是一种口服可用的具有抗肿瘤活性的Bcr-Abl酪氨酸激酶抑制剂。 |
| IC50和靶点: | |
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O'Hare, T., Walters, D.K., Stoffregen, E.P., et al.In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutantsCancer Res.65(11),4500-4505(2005)
La Barbera, L., Vedele, F., Nobili, A., et al.Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of Alzheimer's DiseaseProg. Neurobiol.202,102031(2021)
Iyoda, M., Shibata, T., Hirai, Y., et al.Nilotinib attenuates renal injury and prolongs survival in chronic kidney diseaseJ. Am. Soc. Nephrol.22(8),1486-1496(2011)
