KW-2449
Cat. No.：YN440082
CAS No. ：1000669-72-6
规格
价格(RMB)
库存
| 产品名称: | KW-2449 |
| CAS No.: | 1000669-72-6 |
| Chemical Name: | [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-1-piperazinyl-methanone |
| Synonyms: | KW2449 |
| 分子量: | 332.40 |
| 分子式: | C₂₀H₂₀N₄O |
| SMILES: | O=C(C1=CC=C(/C=C/C2=NNC3=C2C=CC=C3)C=C1)N4CCNCC4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | KW-2449是多靶点激酶抑制剂，对FLT3，ABL，ABLT315I和Aurora kinase的IC50值分别为6.6，14，4 和 48 nM。 |
| IC50和靶点: | [{name:"Abl:4 nM (IC50)"},{name: "ABL-T315I:14 nM (IC50)"},{name: "FGFR1:36 nM (IC50)"},{name: "Aurora A:48 nM (IC50)"},{name: "FLT3/D835Y:1 nM (IC50)"},{name: "FLT3:6.6 nM (IC50)"},{name: "JAK2:150 nM (IC50)"},{name: "SRC:400 nM (IC50)"},{name: "PDFGRα:1700 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Shiotsu, Y., Kiyoi, H., Ishikawa, Y., et al.KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocationBlood114(8),1607-1617(2009)
