PD173955
Cat. No.：YN440089
CAS No. ：260415-63-2
规格
价格(RMB)
库存
| 产品名称: | PD173955 |
| CAS No.: | 260415-63-2 |
| Chemical Name: | 6-(2,6-dichlorophenyl)-8-methyl-2-[[3-(methylthio)phenyl]amino]-pyrido[2,3-d]pyrimidin-7(8H)-one |
| Synonyms: | PD 173955,PD-173955 |
| 分子量: | 443.35 |
| 分子式: | C₂₁H₁₆Cl₂N₄OS |
| SMILES: | O=C1C(C2=C(Cl)C=CC=C2Cl)=CC3=CN=C(NC4=CC=CC(SC)=C4)N=C3N1C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PD173955是Src激酶家族选择性抑制剂，对Src、Yes和Abl激酶IC50值约为22nM，对FGFR_alpha_抑制性弱，对InsR和PKC无活性。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Moasser, M.M., Srethapakdi, M., Sachar, K.S., et al.Inhibition of Src kinases by a selective tyrosine kinase inhibitor causes mitotic arrestCancer Res.59(24),145-152(1999)
Wisniewski, D., Lambek, C.L., Liu, C., et al.Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinasesCancer Res.62(15),4244-4255(2002)
Kraker, A.J., Hartl, B.G., Amar, A.M., et al.Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitorsBiochem. Pharmacol.60(7),885-898(2000)
