GNF-2
Cat. No.：YN440135
CAS No. ：778270-11-4
规格
价格(RMB)
库存
| 产品名称: | GNF-2 |
| CAS No.: | 778270-11-4 |
| Chemical Name: | 3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]-benzamide |
| Synonyms: | GNF2 |
| 分子量: | 374.32 |
| 分子式: | C₁₈H₁₃F₃N₄O₂ |
| SMILES: | O=C(C1=CC=CC(C2=CC(NC3=CC=C(OC(F)(F)F)C=C3)=NC=N2)=C1)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GNF-2 是一种具有高度选择性、变构的、非 ATP 竞争性Bcr-Abl抑制剂。 GNF-2 抑制 Ba/F3.p210 增殖，IC50为 138 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Adrián, F.J., Ding, Q., Sim, T., et al.Allosteric inhibitors of Bcr-abl-dependent cell proliferationNat. Chem. Biol.2(2),95-102(2006)
Sisk, J.M., Frieman, M.B., and Machamer, C.E.Coronavirus S protein-induced fusion is blocked prior to hemifusion by Able kinase inhibitorsJ. Gen. Virol.99(5),619-630(2018)
Song, G.J., Rahman, M.H., Jha, M.K., et al.A Bcr-Abl inhibitor GNF-2 attenuates inflammatory activation of glia and chronic painFront. Pharmacol.10,543(2019)
