Degrasyn
Cat. No.：YN440258
CAS No. ：856243-80-6
规格
价格(RMB)
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| 产品名称: | Degrasyn |
| CAS No.: | 856243-80-6 |
| Chemical Name: | (2E)-3-(6-bromo-2-pyridinyl)-2-cyano-N-[1S-phenylbutyl]-2-propenamide |
| Synonyms: | WP1130 |
| 分子量: | 384.27 |
| 分子式: | C₁₉H₁₈BrN₃O |
| SMILES: | BrC1=CC=CC(/C=C(C(N[C@H](C2=CC=CC=C2)CCC)=O)\C#N)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Degrasyn (WP1130) 是可渗透细胞的去泛素化酶(DUB)抑制剂，直接抑制USP9x，USP5，USP14和UCH37的DUB活性。 Degrasyn 减弱抗细胞凋亡蛋白Bcr-Abl和JAK2。 |
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Kapuria, V., Peterson, L.F., Fang, D., et al.Deubiquitinase inhibition by small-molecule WP1130 triggers aggresome formation and tumor cell apoptosisCancer Res.70(22),9265-9276(2010)
Bartholomeusz, G.A., Talpaz, M., Kapuria, V., et al.Activation of a novel Bcr/Abl destruction pathway by WP1130 induces apoptosis of chronic myelogenous leukemia cellsBlood109(8),3470-3478(2007)
