Nocodazole
Cat. No.：YN440276
CAS No. ：31430-18-9
规格
价格(RMB)
库存
| 产品名称: | Nocodazole |
| CAS No.: | 31430-18-9 |
| Chemical Name: | N-[6-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamic acid, methyl ester |
| Synonyms: | 诺考达唑; Oncodazole; R17934 |
| 分子量: | 301.32 |
| 分子式: | C₁₄H₁₁N₃O₃S |
| SMILES: | O=C(OC)NC1=NC2=CC=C(C(C3=CC=CS3)=O)C=C2N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Nocodazole (Oncodazole) 是快速可逆的microtubule抑制剂。 Nocodazole与β-微管蛋白结合并破坏微管组装/拆卸动力学，从而防止有丝分裂并诱导肿瘤细胞凋亡。Nocodazole 抑制Bcr-Abl，增强CRISPR/Cas9的活性。 |
| IC50和靶点: | [{name:"Abl:91 nM (Kd)"},{name: "ABL(E255K):120 nM (Kd)"},{name: "ABL(T315I):170 nM (Kd)"},{name: "BRAF:1.8 μM (Kd)"},{name: "BRAF(V600E):1.1 μM (Kd)"},{name: "c-KIT:1.6 μM (Kd)"},{name: "MEK1:1.7 μM (Kd)"},{name: "MEK2:1.6 μM (Kd)"},{name: "MET:1.7 μM (Kd)"},{name: "PI3Kγ:1.5 μM (Kd)'}, 'Microtubule/Tubulin', 'CRISPR/Cas9'] |
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