Radotinib
Cat. No.：YN440339
CAS No. ：926037-48-1
规格
价格(RMB)
库存
| 产品名称: | Radotinib |
| CAS No.: | 926037-48-1 |
| Chemical Name: | 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(2-pyrazinyl)-2-pyrimidinyl]amino]-benzamide |
| Synonyms: | IY-5511 |
| 分子量: | 530.50 |
| 分子式: | C₂₇H₂₁F₃N₈O |
| SMILES: | O=C(NC1=CC(C(F)(F)F)=CC(N2C=C(C)N=C2)=C1)C3=CC=C(C)C(NC4=NC=CC(C5=NC=CN=C5)=N4)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Radotinib (IY-5511) 是酪氨酸激酶 Bcr-Abl1 新型选择性抑制剂，对野生型 Bcr-Abl1 的 IC50 值为 34nM。 |
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Zabriskie, M.S., Vellore, N.A., Gantz, K.C., et al.Radotinib is an effective inhibitor of native and kinase domain-mutant BCR-ABL1Leukemia29(9),1939-1942(2015)
Heo, S.-K., Noh, E.-K., Yoon, D.-J., et al.Radotinib induces apoptosis of CD11b+ cells differentiated from acute myeloid leukemia cellsPLoS One10(6),e0129853(2015)
Kim, S.-H., Menon, H., Jootar, S., et al.Efficacy and safety of radotinib in chronic phase chronic myeloid leukemia patients with resistance or intolerance to BCR-ABL1 tyrosine kinase inhibitorsHaematologica99(7),1191-1196(2014)
