GNF-5
Cat. No.：YN440341
CAS No. ：778277-15-9
规格
价格(RMB)
库存
| 产品名称: | GNF-5 |
| CAS No.: | 778277-15-9 |
| Chemical Name: | N-(2-hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]-benzamide |
| Synonyms: | GNF 5 |
| 分子量: | 418.37 |
| 分子式: | C₂₀H₁₇F₃N₄O₃ |
| SMILES: | FC(F)(F)OC(C=C1)=CC=C1NC2=NC=NC(C3=CC=CC(C(NCCO)=O)=C3)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GNF-5是GNF-2的类似物，具有更好的药物动力学活性，是非ATP竞争性的Bcr-Abl抑制剂，IC50为0.22uM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Fabbro, D., Manley, P.W., Jahnke, W., et al.Inhibitors of the Abl kinase directed at either the ATP- or myristate-binding siteBiochim. Biophys. Acta1804(3),454-462(2010)
Zhang, J., Adrián, F.J., Jahnke, W., et al.Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitorsNature463(7280),501-506(2010)
Sisk, J.M., Frieman, M.B., and Machamer, C.E.Coronavirus S protein-induced fusion is blocked prior to hemifusion by Able kinase inhibitorsJ. Gen. Virol.99(5),619-630(2018)
