LY2811376
Cat. No.：YN380026
CAS No. ：1194044-20-6
| 产品名称: | LY2811376 |
| CAS No.: | 1194044-20-6 |
| Chemical Name: | (4S)-4-[2,4-difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-4H-1,3-thiazin-2-amine |
| Synonyms: | (S)-4-(2,4-Difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine;LY2811376;LY2811376;LY-2811376;(4S)-4-[2,4-Difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-4H-1,3-thiazin-2-amine |
| 分子量: | 320.36 |
| 分子式: | C₁₅H₁₄F₂N₄S |
| SMILES: | FC1=C(C2=CN=CN=C2)C=C([C@]3(C)CCSC(N3)=N)C(F)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LY2811376 是一种可口服的，非肽段的β-secretase (BACE1)抑制剂，IC50值为 239 nM-249 nM，能够降低 Aβ 蛋白的分泌，EC50值为 300 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Hong, L., Turner, R.T., III, Koelsch, G., et al.Memapsin 2 (β-secretase) as a therapeutic targetBiochem. Soc. Trans.30(4),530-534(2002)
Grüninger-Leitch, F., Schlatter, D., Küng, E., et al.Substrate and inhibitor profile of BACE (β-secretase) and comparison with other mammalian aspartic proteasesJ. Biol. Chem.277(7),4687-4693(2002)
May, P.C., Dean, R.A., Lowe, S.L., et al.Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitorJ. Neurosci.31(46),16507-16516(2011)
