AZD3839 free base
Cat. No.：YN380078
CAS No. ：1227163-84-9
| 产品名称: | AZD3839 free base |
| CAS No.: | 1227163-84-9 |
| Chemical Name: | (1S)-1-[2-(difluoromethyl)-4-pyridinyl]-4-fluoro-1-[3-(5-pyrimidinyl)phenyl]-1H-isoindol-3-amine |
| Synonyms: | AZD3839 |
| 分子量: | 431.41 |
| 分子式: | C₂₄H₁₆F₃N₅ |
| SMILES: | FC1=C2C([C@](C3=CC=CC(C4=CN=CN=C4)=C3)(C5=CC(C(F)F)=NC=C5)N=C2N)=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZD3839 (free base)是一个强的和选择性的BACE1 inhibitor，IC50是23.6 uM, 也是β-secretase酶的抑制剂。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Jeppsson, F., Eketjäll, S., Janson, J., et al.Discovery of AZD3839, a potent and selective BACE1 inhibitor clinical candidate for the treatment of Alzheimer diseaseJ. Biol. Chem.287(49),41245-41257(2012)
Swahn, B.-M., Kolmodin, K., Karlström, S., et al.Design and synthesis of β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors with in vivo brain reduction of β-amyloid peptidesJ. Med. Chem.55(21),9346-9361(2012)
