Verubecestat
Cat. No.：YN380117
CAS No. ：1286770-55-5
| 产品名称: | Verubecestat |
| CAS No.: | 1286770-55-5 |
| Chemical Name: | N-[3-[(5R)-3-amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide |
| Synonyms: | 维罗司他; MK-8931 |
| 分子量: | 409.41 |
| 分子式: | C₁₇H₁₇F₂N₅O₃S |
| SMILES: | O=C(C1=NC=C(F)C=C1)NC2=CC=C(F)C([C@@](C3)(C)N=C(N)N(C)S3(=O)=O)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Verubecestat (MK-8931) 是一种具有口服活性的，高亲和力BACE1和BACE2抑制剂，Ki值分别为 2.2 nM 和 0.38 nM。Verubecestat 可以有效降低 Aβ40，并具有用于阿尔茨海默氏病的潜力。 |
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Scott, J.D., Li, S.W., Brunskill, A.P.J., et al.Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-dioxide derivative verubecestat (MK-8931)- a β-site amyloid precursor protein cleaving enzyme 1 inhibitor for the treatment of Alzheimer's diseaseJ. Med. Chem.59(23),10435-10450(2016)
Kennedy, M.E., Stamford, A.W., Chen, X., et al.The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patientsSci. Transl. Med.8(363),363ra150(2016)
