Scoulerine
Cat. No.：YN380241
| 产品名称: | Scoulerine |
| CAS No.: | 6451-73-6 |
| Chemical Name: | 5,8,13,13aS-tetrahydro-3,10-dimethoxy-6H-dibenzo[a,g]quinolizine-2,9-diol |
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| 分子量: | 327.37 |
| 分子式: | C₁₉H₂₁NO₄ |
| SMILES: | OC1=C(OC)C=C(CCN2CC3=C(O)C(OC)=CC=C3C[C@]24[H])C4=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Scoulerine ((-)-Scoulerine) 是一种有效的抗有丝分裂 (antimitotic) 化合物。Scoulerine 也是BACE1(淀粉样前体蛋白裂解酶 1) 的抑制剂。Scoulerine 抑制细胞增殖，阻止细胞周期，并诱导癌细胞凋亡。 |
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Sun, H., Zhu, L., Yang, H., et al.Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D1, D2 and serotonin 5-HT1A multi-action profileBioorg. Med. Chem.21(4),856-868(2013)
Habartova, K., Havelek, R., Seifrtova, M., et al.Scoulerine affects microtubule structure, inhibits proliferation, arrests cell cycle and thus culminates in the apoptotic death of cancer cellsSci. Rep.8(1),4829(2018)
Mi, G., Gao, Y., Yan, H., et al.l-Scoulerine attenuates behavioural changes induced by methamphetamine in zebrafish and miceBehav. Brain Res.298(Pt A),97-104(2016)
