BMS-986142
Cat. No.：YN440048
CAS No. ：1643368-58-4
规格
价格(RMB)
库存
| 产品名称: | BMS-986142 |
| CAS No.: | 1643368-58-4 |
| Chemical Name: | (2S,5R)-6-fluoro-5-[(3S)-3-(8-fluoro-1,4-dihydro-1-methyl-2,4-dioxo-3(2H)-quinazolinyl)-2-methylphenyl]-2,3,4,9-tetrahydro-2-(1-hydroxy-1-methylethyl)-1H-carbazole-8-carboxamide |
| Synonyms: | PJX9GH268R;BMS986142;6-Fluoro-5-(R)-(3-(S)-(8-Fluoro-1-Methyl-2,4-Dioxo-1,2-Dihydroquinazolin-3(4h)-Yl)-2-Methylphenyl)-2-(S)-(2-Hydroxypropan-2-Yl)-2,3,4,9-Tetrahydro-1h-Carbazole-8-Carboxamide;GTPL9857;C32H30F2N4O4;BCP29622;BDBM50194720;s8381;ZB1608;DB1 |
| 分子量: | 572.60 |
| 分子式: | C₃₂H₃₀F₂N₄O₄ |
| SMILES: | O=C1C2=C(C(F)=CC=C2)N(C)C(N1C3=C(C)[C@]([C@]4=C(F)C=C(C(N)=O)C5=C4C6=C(C[C@@H](C(C)(C)O)CC6)N5)=CC=C3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BMS-986142 是一种有效的、具有高选择性的Bruton's 酪氨酸激酶 (BTK)可逆性抑制剂，其 IC50值为 0.5 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Watterson, S.H., De Lucca, G.V., Shi, Q., et al.Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A reversible inhibitor of Bruton's tyrosine kinase (BTK) conformationally constrained by two locked atropisomersJ. Med. Chem.59(19),9173-9200(2016)
Gillooly, K.M., Pulicicchio, C., Pattoli, M.A., et al.Bruton's tyrosine kinase inhibitor BMS-986142 in experimental models of rheumatoid arthritis enhances efficacy of agents representing clinical standard-of-carePLoS One12(7),e0181782(2017)
