Ibrutinib D5
Cat. No.：YN440134
CAS No. ：1553977-17-5
规格
价格(RMB)
库存
| 产品名称: | Ibrutinib D5 |
| CAS No.: | 1553977-17-5 |
| Chemical Name: | 1-[(3R)-3-[4-amino-3-[4-(phenoxy-2,3,4,5,6-d5)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one |
| Synonyms: | PCI-32765 D5 |
| 分子量: | 445.53 |
| 分子式: | C₂₅H₁₉D₅N₆O₂ |
| SMILES: | C=CC(N1C[C@H](N2N=C(C3=CC=C(OC4=C([2H])C([2H])=C([2H])C([2H])=C4[2H])C=C3)C5=C(N)N=CN=C52)CCC1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ibrutinib D5 (PCI-32765 D5) 是 Ibrutinib 的一种氘代化合物。Ibrutinib 是一种选择性，不可逆的 Btk 抑制剂。 |
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Honigberg, L.A., Smith, A.M., Sirisawad, M., et al.The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancyProc. Natl. Acad. Sci. USA107(29),13075-13080(2010)
Herman, S.E.M., Gordon, A.L., Hertlein, E., et al.Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765Blood117(23),6287-6296(2011)
Leslie, L.A., and Younes, A.Targeting oncogenic and epigenetic survival pathways in lymphomaLeuk. Lymphoma.54(11),2365-2376(2013)
Wu, M., Akinleye, A., and Zhu, X.Novel agents for chronic lymphocytic leukemiaJ. Hematol. Oncol.6,36(2013)
