Branebrutinib
Cat. No.：YN440150
CAS No. ：1912445-55-6
规格
价格(RMB)
库存
| 产品名称: | Branebrutinib |
| CAS No.: | 1912445-55-6 |
| Chemical Name: | 5-fluoro-2,3-dimethyl-4-[(3S)-3-[(1-oxo-2-butyn-1-yl)amino]-1-piperidinyl]-1H-indole-7-carboxamide |
| Synonyms: | BMS-986195 |
| 分子量: | 370.42 |
| 分子式: | C₂₀H₂₃FN₄O₂ |
| SMILES: | O=C(C1=CC(F)=C(N2C[C@@H](NC(C#CC)=O)CCC2)C3=C1NC(C)=C3C)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Branebrutinib (BMS-986195) 是一个强有效的、布鲁顿氏酪氨酸激酶(BTK)的不可逆共价、选择抑制剂，其IC50值 0.1 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Watterson, S.H., Liu, Q., Bertrand, M.B., et al.Discovery of branebrutinib (BMS-986195): A strategy for identifying a highly potent and selective covalent inhibitor providing rapid in vivo inactivation of Bruton's tyrosine kinase (BTK)J. Med. Chem.62(7),3228-3250(2019)
