CGI-1746
Cat. No.：YN440177
CAS No. ：910232-84-7
规格
价格(RMB)
库存
| 产品名称: | CGI-1746 |
| CAS No.: | 910232-84-7 |
| Chemical Name: | N-[3-[4,5-dihydro-4-methyl-6-[[4-(4-morpholinylcarbonyl)phenyl]amino]-5-oxo-2-pyrazinyl]-2-methylphenyl]-4-(1,1-dimethylethyl)-benzamide |
| Synonyms: | N-[3-[4,5-Dihydro-4-methyl-6-[[4-(4-morpholinylcarbonyl)phenyl]amino]-5-oxo-2-pyrazinyl]-2-methylphenyl]-4-(tert-butyl)benzamide;CGI-1746;4-tert-butyl-N-[2-methyl-3-[4-methyl-6-[4-(morpholine-4-carbonyl)anilino]-5-oxopyrazin-2-yl]phenyl]benzamide;C34H37N5 |
| 分子量: | 579.69 |
| 分子式: | C₃₄H₃₇N₅O₄ |
| SMILES: | O=C(C1=CC=C(C=C1)C(C)(C)C)NC2=CC=CC(C(N=C3NC4=CC=C(C=C4)C(N5CCOCC5)=O)=CN(C3=O)C)=C2C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CGI-1746 是一种有效的，高选择性的Btk抑制剂，IC50值为 1.9 nM。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
di Paolo, J.A., Huang, T., Balazs, M., et al.Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritisNat. Chem. Biol.7(1),41-50(2011)
Akinleye, A., Chen, Y., Mukhi, N., et al.Ibrutinib and novel BTK inhibitors in clinical developmentJ. Hematol. Oncol.6(59),(2013)
