BIIB068
Cat. No.：YN440251
CAS No. ：1798787-27-5
规格
价格(RMB)
库存
| 产品名称: | BIIB068 |
| CAS No.: | 1798787-27-5 |
| Chemical Name: | 3-(1-methylethoxy)-N-[[2-methyl-4-[2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]phenyl]methyl]-1-azetidinecarboxamide |
| Synonyms: | |
| 分子量: | 435.52 |
| 分子式: | C₂₃H₂₉N₇O₂ |
| SMILES: | O=C(N1CC(OC(C)C)C1)NCC2=CC=C(C3=NC(NC4=CN(C)N=C4)=NC=C3)C=C2C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BIIB068 是一种有效，选择性，可逆和具有口服活性的BTK抑制剂，IC50为 1 nM，Kd为 0.3 nM。BIIB068 对BTK的选择性比其他激酶高 400 倍。BIIB068 可用于自身免疫性疾病的研究。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Li, C., Franklin, L., Chen, R., et al.Process development and large-scale synthesis of BTK inhibitor BIIB068Org. Process Res. Dev.24(6),1199-1206(2020)
Hopkins, B.T., Ma, B., Chan, T.R., et al.Biaryl compounds useful for the treatment of human diseases in oncology, neurology, and immunology,(2015)
