CNX-774
Cat. No.：YN440302
CAS No. ：1202759-32-7
规格
价格(RMB)
库存
| 产品名称: | CNX-774 |
| CAS No.: | 1202759-32-7 |
| Chemical Name: | 4-[4-[[5-fluoro-4-[[3-[(1-oxo-2-propen-1-yl)amino]phenyl]amino]-2-pyrimidinyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide |
| Synonyms: | CNX 774 |
| 分子量: | 499.50 |
| 分子式: | C₂₆H₂₂FN₇O₃ |
| SMILES: | O=C(NC)C1=NC=CC(OC2=CC=C(NC3=NC=C(F)C(NC4=CC=CC(NC(C=C)=O)=C4)=N3)C=C2)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CNX-774 是具有口服活性的、不可逆的、选择性的BTK抑制剂，其IC50小于 1 nM。CNX-774 特异性靶向 Btk 的 Cys 481进行共价修饰。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Akinleye, A., Chen, Y., Mukhi, N., et al.Ibrutinib and novel BTK inhibitors in clinical developmentJ. Hematol. Oncol.6(59),(2013)
Smilijkovic, D., Blatt, K., Stefanzl, G., et al.BTK inhibition is a potent approach to block IgE-mediated histamine release in human basophilsAllergy,1-11(2017)
