Tirabrutinib
Cat. No.：YN440344
CAS No. ：1351636-18-4
规格
价格(RMB)
库存
| 产品名称: | Tirabrutinib |
| CAS No.: | 1351636-18-4 |
| Chemical Name: | 6-amino-7,9-dihydro-9-[(3R)-1-(1-oxo-2-butyn-1-yl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-8H-purin-8-one |
| Synonyms: | ONO-4059; GS-4059 |
| 分子量: | 454.48 |
| 分子式: | C₂₅H₂₂N₆O₃ |
| SMILES: | O=C1N(C2=CC=C(OC3=CC=CC=C3)C=C2)C4=C(N)N=CN=C4N1[C@H]5CN(C(C#CC)=O)CC5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tirabrutinib (ONO-4059) 是高选择性，可口服的BTK抑制剂，IC50为2.2 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Burger, A.Bruton's tyrosine kinase (BTK) inhibitors in clinical trialsCurr. Hematol. Malig. Rep.9(1),44-49(2014)
Yasuhiro, T., Yoshizawa, T., Daub, H., et al.Abstract 2021: ONO-WG-307, a novel, potent and selective inhibitor of Bruton's tyrosine kinase (Btk), results in sustained inhibition of the ERK, AKT and PKD signaling pathwaysCancer Res.72(8 Supplement),2021(2012)
Kozaki, R., Yoshizawa, T., Tohda, S., et al.Abstract 3731: Development of a Bruton's tyrosine kinase (Btk) inhibitor, ONO-WG-307: Efficacy in ABC-DLBCL xenograft model – potential treatment for B-cell malignanciesBlood118(21),3731(2011)
