Tirabrutinib hydrochloride
Cat. No.：YN440345
CAS No. ：1439901-97-9
规格
价格(RMB)
库存
| 产品名称: | Tirabrutinib hydrochloride |
| CAS No.: | 1439901-97-9 |
| Chemical Name: | 6-amino-7,9-dihydro-9-[(3R)-1-(1-oxo-2-butyn-1-yl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-8H-purin-8-one, monohydrochloride |
| Synonyms: | ONO-4059 hydrochloride; GS-4059 hydrochloride |
| 分子量: | 490.94 |
| 分子式: | C₂₅H₂₃ClN₆O₃ |
| SMILES: | O=C1N(C2=CC=C(OC3=CC=CC=C3)C=C2)C4=C(N)N=CN=C4N1[C@H]5CN(C(C#CC)=O)CC5.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tirabrutinib (ONO-4059) hydrochloride 的 IC50值是2.2 nm，是一种有选择性和新颖的抑制剂。 在B细胞中ONO-4058结合BTK，因此阻止B细胞受体信号和阻碍B细胞的发展。 |
| IC50和靶点: | [{name:"BMX:6 nM (IC50)"},{name: "BTK:6.8 nM (IC50)"},{name: "TEC:48 nM (IC50)"},{name: "TXK:92 nM (IC50)"},{name: "BLK:0.3 μM (IC50)"},{name: "ERBB4:0.77 μM (IC50)"},{name: "EGFR:3.02 μM (IC50)"},{name: "JAK3:5.52 μM (IC50)"},{name: "ERBB2:7.31 μM (IC50)"}] |
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| Solvent & Solubility: |
Burger, A.Bruton's tyrosine kinase (BTK) inhibitors in clinical trialsCurr. Hematol. Malig. Rep.9(1),44-49(2014)
Yasuhiro, T., Yoshizawa, T., Daub, H., et al.Abstract 2021: ONO-WG-307, a novel, potent and selective inhibitor of Bruton's tyrosine kinase (Btk), results in sustained inhibition of the ERK, AKT and PKD signaling pathwaysCancer Res.72(8 Supplement),2021(2012)
Kozaki, R., Yoshizawa, T., Tohda, S., et al.Abstract 3731: Development of a Bruton's tyrosine kinase (Btk) inhibitor, ONO-WG-307: Efficacy in ABC-DLBCL xenograft model – potential treatment for B-cell malignanciesBlood118(21),3731(2011)
