Fenebrutinib
Cat. No.：YN440393
CAS No. ：1434048-34-6
规格
价格(RMB)
库存
| 产品名称: | Fenebrutinib |
| CAS No.: | 1434048-34-6 |
| Chemical Name: | 2-[1,6-dihydro-3'-(hydroxymethyl)-1-methyl-5-[[5-[(2S)-2-methyl-4-(3-oxetanyl)-1-piperazinyl]-2-pyridinyl]amino]-6-oxo[3,4'-bipyridin]-2'-yl]-3,4,7,8-tetrahydro-7,7-dimethyl-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one |
| Synonyms: | GDC-0853 |
| 分子量: | 664.80 |
| 分子式: | C₃₇H₄₄N₈O₄ |
| SMILES: | O=C1C(NC(C=C2)=NC=C2N3CCN(C4COC4)C[C@@H]3C)=CC(C5=CC=NC(N6C(C7=CC(CC(C)(C)C8)=C8N7CC6)=O)=C5CO)=CN1C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Fenebrutinib (GDC-0853) 是一种有效的，具有口服活性的，选择性和非共价的布鲁顿酪氨酸激酶 (Btk) 抑制剂，对野生型 Btk，及突变型 C481S，C481R，T474I，T474M 的Ki分别为 0.91 nM，1.6，1.3，12.6 和 3.4 nM。有潜力用于类风湿关节炎和系统性红斑狼疮的研究。 |
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Crawford, J.J., Johnson, A.R., Misner, D.L., et al.Discovery of GDC-0853: A potent, selective, and noncovalent Bruton's tyrosine kinase inhibitor in early clinical developmentJ. Med. Chem.61(6),2227-2245(2018)
