MSC2530818
Cat. No.：YN290034
CAS No. ：1883423-59-3
| 产品名称: | MSC2530818 |
| CAS No.: | 1883423-59-3 |
| Chemical Name: | [(2S)-2-(4-chlorophenyl)-1-pyrrolidinyl](3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-methanone |
| Synonyms: | |
| 分子量: | 340.81 |
| 分子式: | C₁₈H₁₇ClN₄O |
| SMILES: | O=C(N1[C@H](C2=CC=C(Cl)C=C2)CCC1)C3=CN=C(NN=C4C)C4=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MSC2530818是有效，选择性，有口服活性的CDK8抑制剂，抑制 CDK8 的IC50值为2.6 nM。 |
| IC50和靶点: | [{name:"CDK8:2.6 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Czodrowski, P., Mallinger, A., Wienke, D., et al.Structure-based optimization of potent, selective, and orally bioavailable CDK8 inhibitors discovered by high-throughput screeningJ. Med. Chem.59(20),9337-9349(2016)
