THZ531
Cat. No.：YN290056
CAS No. ：1702809-17-3
| 产品名称: | THZ531 |
| CAS No.: | 1702809-17-3 |
| Chemical Name: | (2E)-N-[4-[[(3R)-3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]-1-piperidinyl]carbonyl]phenyl]-4-(dimethylamino)-2-butenamide |
| Synonyms: | THZ531; THZ-531; THZ 531 |
| 分子量: | 558.07 |
| 分子式: | C₃₀H₃₂ClN₇O₂ |
| SMILES: | ClC(C(C1=CNC2=CC=CC=C12)=N3)=CN=C3N[C@@H]4CCCN(C(C5=CC=C(NC(/C=C/CN(C)C)=O)C=C5)=O)C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | THZ531 是选择性的CDK12和CDK13的共价抑制剂，IC50值分别为 158 nM 和 69 nM。 |
| IC50和靶点: | [{name:"CDK12:158 nM (IC50)"},{name: "CDK13:69 nM (IC50)"},{name: "CDK7:8.5 μM (IC50)"},{name: "CDK9:10.5 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Zhang, T., Kwiatkowski, N., Olson, C.M., et al.Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitorsNat. Chem. Biol.12(10),876-884(2016)
