SEL120-34A HCl
Cat. No.：YN290101
| 产品名称: | SEL120-34A HCl |
| CAS No.: | 1609452-30-3 |
| Chemical Name: | 7,8-dibromo-5,6-dihydro-9-methyl-2-(1-piperazinyl)-4H-imidazo[4,5,1-ij]quinoline, hydrochloride |
| Synonyms: | SEL 120-34A |
| 分子量: | 暂无 |
| 分子式: | C₁₅H₁₈Br₂N₄.xHCl |
| SMILES: | CC1=C(Br)C(Br)=C2C3=C1N=C(N4CCNCC4)N3CCC2.[x HCl] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SEL120-34A HCl 是一种有效的，选择性的，可口服的，ATP-竞争性的CDK8抑制剂，对 CDK8/CycC 和 CDK19/CycC 的IC50值分别为 4.4 nM 和 10.4 nM，具有抗肿瘤活性。 |
| IC50和靶点: | [{name:"CDK8/CycC:4.4 nM (IC50)"},{name: "CDK19/CycC:10.4 nM (IC50)"},{name: "CDK9/cycT:1070 nM (IC50)"}] |
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Rzymski, T., Mikula, M., Żyłkiewicz, E., et al.SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domainsOncotarget8(20),33779-33795(2017)
