PNU112455A hydrochloride
Cat. No.：YN290132
| 产品名称: | PNU112455A hydrochloride |
| CAS No.: | 21886-12-4 |
| Chemical Name: | 4-[(6-amino-4-pyrimidinyl)amino]-benzenesulfonamide, monohydrochloride |
| Synonyms: | PNU 112455A |
| 分子量: | 301.75 |
| 分子式: | C₁₀H₁₂ClN₅O₂S |
| SMILES: | O=S(C1=CC=C(NC2=NC=NC(N)=C2)C=C1)(N)=O.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PNU112455A hydrochloride 是一种 ATP 竞争性的CDK2/CDK5抑制剂。PNU112455A hydrochloride 结合 CDK2/CDK5 ATP 结合位点的Km值为 3.6 和 3.2 μM。 |
| IC50和靶点: | [{name:"CDK2:3.6 μM (Km)"},{name: "CDK5:3.2 μM (Km)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Clare, P.M., Poorman, R.A., Kelley, L.C., et al.The cyclin-dependent kinases cdk2 and cdk5 act by a random, anticooperative kinetic mechanismJ. Biol. Chem.276(51),48292-48299(2001)
Sotiropoulos, I., Catania, C., Riedemann, T., et al.Glucocorticoids trigger Alzheimer disease-like pathobiochemistry in rat neuronal cells expressing human tauJ. Neurochem.107(2),385-397(2008)
